[1] Pyles began modeling at age eight[2] for clothing brands and retail store advertisements.

In 2016, Pyles started landing TV roles in shows such as Nickelodeon's Bella and the Bulldogs, ABC's Speechless, The Fosters, and How to Get Away with Murder.

[5] In 2022, Pyles gained international recognition when she began portraying Minnie "Mouse" Honrada, a 15-year-old high school student, in HBO Max's critically acclaimed drama series Pretty Little Liars: Original Sin.

In October of the same year, the new season was teased under the title Pretty Little Liars: Summer School.

[10] On October 24, 2022, Pyles officially announced her relationship with Pretty Little Liars: Original Sin co-star Jordan Gonzalez after they appeared in a Halloween photoshoot together.