His lack of game experience and issues with tackle consistency will likely show themselves early in his career, but his ability to flip the field is worthy of an aggressive projection.

122 NFL scouts and representatives attended Ohio State's Pro Day as well as multiple head coaches, including Bill Belichick (New England Patriots), Todd Bowles (New York Jets), Jim Caldwell (Detroit Lions), John Harbaugh (Baltimore Ravens), Hue Jackson (Cleveland Browns), Marvin Lewis (Cincinnati Bengals), Mike Mularkey (Tennessee Titans), Sean Payton (New Orleans Saints), and Mike Tomlin (Pittsburgh Steelers).

[24] On September 10, 2017, Hooker made his professional regular season debut in the Indianapolis Colts' season-opener at the Los Angeles Rams and recorded four combined tackles (three solo) in their 46–9 loss.

[25] On September 17, 2017, Hooker earned his first career start in place of Darius Butler, who was inactive after sustaining a hamstring injury in Week 1.

[27] Defensive coordinator Ted Monachino named Hooker the starting free safety for the remainder of the season, supplanting Darius Butler.

[25] In Week 7, Hooker made two solo tackles before leaving the Colts' 27–0 loss to the Jacksonville Jaguars in the second quarter after suffering a torn ACL and MCL.

[28] On October 24, 2017, the Indianapolis Colts officially placed Hooker on injured reserve after it was discovered he would require surgery and miss the remainder of the season.

[29] On December 31 2017, the Indianapolis Colts announced their decision to fire head coach Chuck Pagano after they finished the 2017 NFL season with a 4-12 record.

[30] On February 11, 2018, the Indianapolis Colts announced their decision to hire former Philadelphia Eagles' offensive coordinator Frank Reich as their new head coach.

[31] He entered training camp projected to win the role as the starting free safety following the departure of Darius Butler.

The following week, he recorded one solo tackle and made his first interception of the season off a pass thrown by rookie quarterback Sam Darnold and returned it for 27–yards in the 42–34 loss at the New York Jets.

[38] He unfortunately injured his foot during the game and was subsequently unable to participate in the Colts' 31–13 loss at the Kansas City Chiefs in the Divisional Round.

Head coach Frank Reich retained Hooker and Clayton Geathers as the starting safety tandem to begin the season.

He finished the 2019 NFL season with 51 combined tackles (30 solo), three pass deflections, two interceptions, and one fumble recovery in 13 games and 13 starts.

Throughout training camp, he competed against Khari Willis, Tavon Wilson, Ibraheim Campbell, Julian Blackmon, and George Odum.

[47] Throughout training camp, he competed to be a starting safety against Damontae Kazee, Jayron Kearse, Donovan Wilson, Keanu Neal, and Israel Mukuamu.

[49][50] During training camp, defensive coordinator Dan Quinn held a competition between Hooker, Jayron Kearse, and Israel Mukuamu to name a new starting free safety to replace Damontae Kazee.

On December 4, 2022, Hooker recorded two solo tackles, made a pass deflection, one interception, and returned a fumble recovery for his first career touchdown during a 54–19 win against the Indianapolis Colts.

He finished the season with 62 combined tackles (44 solo), three pass deflections, three interceptions, one fumble recovery, and one touchdown in 16 games and six starts.

On January 16, 2023, he started in the NFC Wildcard Game and made six combined tackles (five solo) during a 31–14 win at the Tampa Bay Buccaneers.

[56] The Dallas Cowboys fired Mike Zimmer as their new defensive coordinator after Dan Quinn accepted the head coaching position with the Washington Commanders.

[57] On November 18, 2024, Hooker made eight combined tackles (three solo), a pass deflection, and returned an interception thrown by C. J. Stroud to wide receiver Nico Collins for 21–yards during a 10–34 loss against the Houston Texans.