He played college football for the Miami Hurricanes and was selected by the Indianapolis Colts in the first round of the 2015 NFL draft.

He has also played for the New England Patriots, Jacksonville Jaguars, Seattle Seahawks, Houston Texans, and Denver Broncos.

Dorsett attended St. Thomas Aquinas High School in Fort Lauderdale, Florida, where he was a two-sport star in football and track.

As a senior, he had 35 receptions for 806 yards and 12 touchdowns in an undefeated season, winning Florida 5A football championship as well as finishing first in the Powerade Fab 50 ESPN Rise national poll.

Also a standout track & field athlete, Dorsett was one of the state's top performers in both the sprinting and jumping events.

As a sophomore in 2012, he played in 12 games with 10 starts and led the team with 58 receptions for 842 yards and four touchdowns.

He competed in the 60-meter dash and posted a best of 6.80 seconds, the fourth fastest time in that event at Miami.

[16] The drafting of Dorsett was a surprise to many analysts and fans, considering Indianapolis already had depth at the wide receiver position, including the recently signed Andre Johnson and Duron Carter, and the selection reportedly upset several Colts players, who thought the team should have instead focused on a defensive player.

During Week 15 against the Minnesota Vikings, he caught his second and final touchdown of the season on a 50-yard pass from Andrew Luck.

[23] Despite his limited playing time, he caught a 31-yard pass on a flea-flicker from Tom Brady in the AFC Championship Game against the Jaguars as the Patriots won by a score of 24–20, advancing to Super Bowl LII.

In the Super Bowl, Dorsett recorded one catch for 19 yards as the Patriots lost to the Philadelphia Eagles by a score of 41–33.

[24] On May 2, 2018, the Patriots declined the fifth-year option on Dorsett's contract, making him a free agent in 2019.

[27] In the divisional playoff game against the Los Angeles Chargers, Dorsett had four receptions for 41 yards and a touchdown.

[29][30] The Patriots reached Super Bowl LIII and defeated the Los Angeles Rams by a score of 13–3,[31] but Dorsett did not record a reception in the game.

[37] After not playing in the team's first two games while nursing a foot injury, Dorsett was placed on injured reserve on September 22, 2020.