Surrounding area might have loss of sensation This is due to the fact that the nerves are no longer working properly.

This condition results from denervation of areas exposed to day-to-day friction of bony prominences.

In insensitive foot, such as in diabetic neuropathy, soft tissues are exposed to excessive pressures without knowledge of the individual.

This leads to punched-out, painless ulcers usually under metatarsal heads, tip of toe, or proximal interphalangeal joint of a hammertoe or on the heel.

It has been shown that ultrasound may increase the acceptance of a graft at trophic ulcer sites.