The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating messenger RNA polyadenylation.

[1] This ribozyme is highly conserved and found only in mammals.

[2] Other HDV-like ribozymes have been identified and confirmed to be active in vitro in a number of eukaryotes.

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