[6] It is surrounded by Komaram Bheem, Nirmal, Jagtial, Peddapalli and Bhupalpally districts of Telangana and with Maharashtra state.

The district is spread over an area of 4,056.36 square kilometres (1,566.17 sq mi).

[17] In Mancherial District, The large,small and micro scale industries are located.

[18] Mancherial is well connected with all types of transport facilities major are Road and Rail.

NH 63 Jagdalpur to yedashi via renapur latur bodhan nizamabad passes through Mancherial.

Also another new National highway is sanctioned from Jaipur Mandal to Warangal via Manthani and Bhupalpally.