After Eccles, the line branched off in a north westerly direction crossing what is now the M602 motorway, calling at stations at Monton Green and Worsley.
After Roe Green the line split, with one branch continuing to Bolton; and the Manchester to Wigan line continuing westward to stations at Ellenbrook and Tyldesley.
After Tyldesley the line split, the Tyldesley Loopline continued to Kenyon Junction while the Wigan line continued to the north west to Howe Bridge Station before crossing the Bolton and Leigh Railway line.
The next station was Hindley Green on the northerly (straight) section and it then passed Platt Bridge and approached a complex junction south of Wigan on what is now the West Coast Main Line.
Sidings for Shakerley Collieries (Ramsden's) and the Tyldesley Coal Company (Greens) were located to the east of Tyldesley Station and for Fletcher, Burrows and Company's Chanters Colliery between Tyldesley and Howe Bridge.