The daughter of senior actor Mohan Babu, Manchu holds a bachelor's degree in theatre from Oklahoma City University.

Manchu made her acting debut with the American television series Las Vegas, where she played the minor role of Sarasvati Kumar, the love interest of James Lesure.

[4] She then appeared in one episode of each of the following series: Desperate Housewives, Late Nights with my Lover, and Mystery ER.

[5] She made her theatre debut as Miss Trunchbull in the adaptation of Roald Dahl's Matilda, directed by Taher Ali Baig, in 2016.

In December 2011, she was signed on to portray a supporting role in Mani Ratnam's Tamil film Kadal after a successful audition.