Manel Esteller

[1] Manel Esteller is the director of the Cancer Epigenetics and Biology Program (PEBC) of the Bellvitge Institute for Biomedical Research (IDIBELL), leader of the Cancer Epigenetics Group, professor of Genetics in the School of Medicine of the University of Barcelona, and research professor at the Catalan Institution for Research and Advanced Studies (ICREA).

Starting from identical genetic sequences, changes in histone modifications and DNA methylation can produce organisms with different features and distinct susceptibility to sickness.

This could have a huge impact in cancer patients, because malignant cells have a profound dysregulation of DNA methylation and histone modification patterns.

The good news is that the first pharmacological compounds to "restore" the normal epigenetic landscapes are starting to emerge.

[4][5] Esteller edited the book "DNA Methylation: Approaches, Methods and Applications" - in the book, he attempts to explain to readers how DNA methylation plays a role in disease, particularly the role in cancer.