Mangalore–Chennai Mail is a Superfast Mail daily train operated by the Indian Railways (Southern Railway) between the cities of Chennai (Madras) and Mangaluru via Salem, Podanur, Palakkad, Shoranur, Tirur, Parapanangadi, Kozhikode, Kannur and Kasaragod.

It runs always full by having more stoppages in northern Kerala beginning from Palakkad Junction to Kasaragod.

It was one single Composite Train called as “01UP/02DOWN Mail” from Madras to Old Coimbatore (Now Podanur) and from there to Chaliyam (now Beypore in Calicut).

The Kerala Mainline was further extended to Kumbla (near Mangalore) which was completed on July 3rd 1907.

At present it runs with train numbers 12601/12602 Chennai- Mangalore Mail.