The Manila East Road, also known as National Road and National Highway, is a two-to-four lane primary and secondary highway connecting Metro Manila to the provinces of Rizal and Laguna in the Philippines.

It will then follow a route that circumscribes Laguna de Bay, passing through the municipalities of Angono, Binangonan, Cardona, Morong, Baras, Tanay, and Pililla in Rizal and Mabitac, Famy, Siniloan, Pangil, Pakil, Paete, Kalayaan, Lumban, and Pagsanjan in Laguna.

[6] Its section designated as N602, from Famy to Pagsanjan, forms part of Calamba–Santa Cruz–Famy Junction Road.

The highway is also locally known as the following within respective poblacions:[1] The highway used to start in or near Manila and took the present-day alignment of J.P. Rizal Avenue in Makati (formerly part of Rizal), branching off from Santa Ana, Manila,[7][8] and later the present-day alignments of P. Sanchez Street in Santa Mesa and Shaw Boulevard.

[9] It was also designated as part of Highway 21 that linked the city of Manila with the provinces of Rizal and Laguna to the east, especially during the American colonial era.