Ortigas Avenue is a 12.1 km (7.5 mi) highway connecting eastern Metro Manila and western Rizal in the Philippines.

The portion of Ortigas Avenue from EDSA–Ortigas Interchange, Quezon City to the Buli Bridge at the Pasig–Cainta boundary is designated as Radial Road 5 (R-5).

[2][3][4] Ortigas Avenue cuts eastwards from the city boundary of San Juan and Quezon City in Metro Manila to Antipolo in Rizal, passing through residential, industrial, and commercial areas, including Ortigas Center, its namesake central business district.

The avenue soon cuts through Ugong, enters Pasig, and crosses Circumferential Road 5 at the C5–Ortigas Interchange, where Bridgetowne real estate development is located.

[6] On August 18, 2023, San Juan Mayor Francis Zamora issued an advisory stating that the city has removed the bollards along the Ortigas Avenue bicycle lanes to be replaced with cat eye markers.