It is a substandard highway through Whiteshell Park, more comparable to a Provincial Road with little to no shoulder and an uneven driving surface.

[2] PTH 44 begins in the Rural Municipality of St. Andrews at an intersection with PTH 9 in Lockport, with the road heading southeast as a two-lane highway through neighborhoods to have an intersection with PR 238 (River Road) and cross the Red River via the St. Andrews Caméré Curtain Bridge Dam.

It leaves Beausejour, traveling across the Brokenhead River and past the communities of St. Ouens and Golden Bay to start straddling the border between the Rural Municipalities of Lac du Bonnet and Reynolds for the next several kilometers.

PTH 44 travels through the community of Rennie before entering Whiteshell Province Park, with the road becoming narrow and windy for the next 31 kilometres (19 mi) after an intersection with PR 307.

It joins the La Vérendrye Trail here, traveling through remote sections of the park, junctioning with PR 312 as it goes around the western side of West Hawk Lake.