Provincial Road 453 (PR 453) is a 24.6-kilometre-long (15.3 mi) east–west highway in the Westman Region of Manitoba.

It provides the primary road access to the hamlet of Rounthwaite, as well as to the south side of the Brandon Hills Wildlife Management Area.

PR 453 begins several kilometres to the south of Brandon at a junction with PTH 10 (John Bracken Highway), heading east along Road 47N on the south side of the Brandon Hills Wildlife Management Area for a few kilometres before making an abrupt right turn onto Road 107W.

After crossing a marshland and a small creek, it makes a left turn onto Road 46N, following it through rural farmland.

The entire length of PR 453 is a gravel, two lane highway, wholly within the Municipality of Oakland-Wawanesa.