The highway runs north through Brandon, Dauphin, Swan River, and The Pas to the Saskatchewan boundary at Flin Flon.

[2] PTH 10 is designated as the John Bracken Highway between the International Peace Garden and Riding Mountain National Park, and the Northern Woods and Water Route between Dauphin and The Pas.

PTH 1 was reconfigured to its current route in 1959[8] and included as part of the Trans-Canada Highway system three years later.

[11] The original section of PTH 10 was redesignated as PR 262 when the provincial government implemented its secondary highway system in 1966.

[15] On July 18, 2016, the southernmost section of PTH 10 was designated as the John Bracken Highway in honour of Manitoba's premier between 1922 and 1943.

Provincial Road 262 (PR 262) is a 69.4-kilometre-long (43.1 mi) north-south loop off of PTH 10 in the Rural Municipalities of Minto-Odanah, Clanwilliam-Erickson, and Harrison Park, as well as running through the town of Minnedosa.

Provincial Road 268 (PR 268), also known as the Lenswood Highway, is a 45-kilometre-long (28 mi) north-south loop off of PTH 10 within the Swan River Valley in the rural municipalities of Minitonas-Bowsman and Mountain, serving as the main road access to the hamlet of Lenswood, as well as a short cut for travelers on PTH 10 wishing to bypass Swan River.

Provincial Road 273 (PR 273) is a 7.1-kilometre-long (4.4 mi) east-west spur of PTH 10 in the Rural Municipalities of Ethelbert and Mossey River, linking the highway to the small hamlet of Ukraina.

It heads northeast through downtown for several blocks to cross a railroad line and have an intersection with PR 289 (Lathlin Avenue), which leads to The Pas/Grace Lake Airport.

The highway travels past the Margaret Barbour Collegiate Institute and a middle school to have an intersection with Fafard Avenue, which provides access to the University College of the North, before leaving town (but not the city limits) and heading east through woodlands.

While approaching the coastline of Grace Lake, the highway officially leaves The Pas and enters the Rural Municipality of Kelsey, where it becomes unpaved.

It is entirely a two-lane gravel road, travelling through rural farmland with the only settlement of notion being the tiny locality of Croll.

It is a two-lane unpaved gravel road for its entire length, winding its way through hilly and remote wooded terrain.

Provincial Road 443 (PR 443) is a 13.3-kilometre-long (8.3 mi) spur of PTH 10 in the southern portion of the Westman Region, providing a connection between the towns of Boissevain and Ninga.

Provincial Road 483 (PR 483) is a 27.3-kilometre-long (17.0 mi) east-west spur of PTH 10 in the Rural Municipality of Mountain and the Sapotaweyak Cree Nation.

It winds its way southeast along the coastline of Namew Lake for several kilometres to come to a three-way stop, where it makes a sharp left.

The road now widens to a two-lane gravel highway and heads due east through remote woodlands for 25 kilometres (16 mi), travelling past several small lakes before crossing the Keewatin Railway at Atik and coming to an end shortly thereafter at an intersection with PTH 10 between Cranberry Portage and Wanless.