Manitou is a town in Tillman County, Oklahoma, United States.

[5] According to the United States Census Bureau, the town has a total area of 0.3 square miles (0.78 km2), all land.

Manitou is served by U.S. Route 183, and is the eastern terminus of State Highway 5C.

[8] Frederick Regional Airport (KFDR; FAA ID: FDR), with a 6099 x 150 ft. paved runway, is approximately 11 miles south of town.

[9] Commercial air transportation is available out of Lawton-Fort Sill Regional Airport, about 38 miles to the east,[10] or the larger Will Rogers World Airport in Oklahoma City, about 121 miles northeast.