One runs for 20.42 miles (32.86 km)[1][2] through extreme southwestern Oklahoma, passing through Harmon and Jackson Counties.

The western SH-5 begins at U.S. Highway 62 in Gould, Oklahoma and runs south until just past Lincoln, where it turns east.

The highway splits off to the east from here, sharing a three-mile (4.8 km) concurrency with US-277/281 and an interchange with Interstate 44 (which is also the Walters toll plaza of the H.E.

Five miles (8 km) east of where this three-route concurrency breaks up, SH-5 turns south in Walters, with the mainline being taken over by State Highway 53.

SH-5 heads east again toward Temple, where it has a brief concurrency with State Highway 65, and then turns southeast to pass through Hastings before ending at US-70 in Waurika.