His parents came from the small village of Agioi Vavatsinias, in the district of Larnaca, Cyprus.
He composed many well-known Greek songs and has co-operated with various important composers, singers and lyricists like Mikis Theodorakis, Haris Alexiou, George Dalaras, Vasilis Papakonstantinou, Christos Leontis, Fondas Ladis, Yannis Negrepontis, Manolis Rasoulis, Giannis Kalatzis, Nâzım Hikmet and many others.
His best known co-operation was with his very personal friend, lyricist Lefteris Papadopoulos who wrote the lyrics of many of Loizos' most successful hits.
Some of Loizos' most famous songs are : In 1985, a big concert dedicated to his memory took place in the Athens Olympic Stadium, attended by more than 50,000 people with singers George Dalaras, Haris Alexiou, Giannis Kalatzis, Dimitra Galani and Vasilis Papakonstantinou performing.
Manos Loizos' songs and music remain popular until today among all ages of the Greek society.