He enrolled at the Law School of the University of Athens but stopped during his third year in order to work as a journalist.
Since 1959 Papadopoulos has worked in the newspaper Ta Nea and has become a popular columnist over time.
He has written the lyrics for about 1,200 songs and has co-worked with nearly all of the well-known musicians, composers and singers of his generation, namely Mikis Theodorakis, Stavros Xarhakos, Manos Loizos, Stavros Koujioumtzis, Mimis Plessas, Christos Nikolopoulos, Stelios Kazantzidis, Grigoris Bithikotsis, George Dalaras, Marinella, Viki Mosholiou and others.
In 1969, composer Mimis Plessas's work of songs "O Dromos", to which Papadopoulos contributed the lyrics, became the fastest selling Greek album.
[citation needed] Of all the creative partnerships that Papadopoulos has had with Greek composers, that of his close friend Manos Loizos is considered a landmark of his career.