He studied at the National and Kapodistrian University of Athens in the chemistry department and during 1941 and 1944 he was a member of EPON.
[4][5] In 1945, with a scholarship from the French Institute, he left for studies in Paris on the ship "Mataroa" together with other young people who later excelle Kostas Axelos, Memos Makris etc.
In 1979 he returned to Greece and from 1981 took over the field of cinema at the Ministry of Culture until 1990.
[8][9][10][11] He met and married his wife, Liolia and they had two daughters, Lena and Masha.
[15] In 2008, the 49th Thessaloniki Film Festival paid tribute to Manos Zacharias[16] under the title The traveler of memory, in the context of which Zacharias' films The Truth for the Children of Greece (1948), Morning Route (1959), The Mops (1960) were screened ), Night Passenger (1962), End and Beginning (1963), I'm a Soldier, Mom (1966),[17] One of the Firing Squad (1968), City of First Love (1970), Corner of Arbat and Bouboulinas (1972), Alias Lukacs (1977) as well as the documentary The Story of My Years - Manos Zacharias (2005) by Stelios Charalambopoulos.