Mansfield Road Baptist Church has its origins in a split within the congregation of Stoney Street Baptist Church in Nottingham in 1849.

In 1863 they appointed as minister Samuel Cox, a very active journalist and author, whose 1877 book 'Salvator Mundi' was a major irritant to Charles Spurgeon, who suspected Cox of being a universalist.

In 1901 they were joined by the congregation of Broad Street Baptist Church.

In 1912 they moved out to the current church which was newly built on the corner of Gregory Boulevard and Sherwood Rise.

The Milton Street chapel was sold, and became a lecture hall for the adjacent Nottingham Mechanics' Institution.