Mantle zone

The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.

[2] It contains transient lymphocytes.

[3] It is the location of the lymphoma in mantle cell lymphoma.

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma.

Tcl-1 is expressed in the mantle zone.

Image labeled in German, but "Mantel-zone" visible near center
Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain