Specifically, the white pulp encompasses several areas with distinct functions: The T cell zone (periarteriolar sheath) and B cell follicles contain discrete macrophage populations; however, not much is known about these macrophage populations in terms of their origin and lifespan.

B cells that cannot form their appropriate receptors will die of apoptosis and are subsequently cleared by the macrophages in the germinal centre.

During intensive germinal centre reactions, this process is obvious due to the presence of the large macrophages in the germinal centre, known as tingible body macrophages, so named because their 'tingible bodies' represent condensed apoptotic nuclei.

Due to them being positioned alongside T cells, it is suggested that these macrophages have a role in antigen presentation or the removal of dying lymphocytes.

[1] This article incorporates text in the public domain from page 1285 of the 20th edition of Gray's Anatomy (1918)