[7] Plant species found in the lowland rainforest zone of the park include: Bertholletia excelsa, Nectandra spp., Cedrelinga cateniformis, Socratea exorrhiza, Eugenia spp., Cedrela odorata, Brosimum lactescens, Iriartea deltoidea, Protium spp., Poulsenia armata, Cecropia spp., Inga spp., Margaritaria nobilis, Ceiba samauma, Solanum grandiflorum, Annona excellens, Calophyllum brasiliense, Simarouba amara, Maxillaria spp., Virola calophylla, Ficus spp., Trema micrantha, Hevea brasiliensis, Piper spp., Mauritia flexuosa, Clusia spp., Euterpe precatoria, Jacaranda copaia, etc.

Plant species found in the mountain zones in the park include: Podocarpus oleifolius, Prunus integrifolia, Cyrtochilum aureum, Escallonia myrtilloides, Hesperomeles ferruginea, Otoglossum scansor, Baccharis salicifolia, Cinchona pubescens, Oreopanax spp., Polylepis pauta, Alnus acuminata, Retrophyllum rospigliosii, Vallea stipularis, etc.

DNA analysis revealed it to be related to the Picramniaceae; but unlike this family, the Aenigmanu has stipules on its stems where the leaves emerge.

[1] Mammals found in the lowland rainforest zone of the park include: the jaguar, the tayra, the giant armadillo, the puma (also present in mountainous areas), the ocelot, the collared peccary, the giant otter, the Peruvian spider monkey, the Mexican free-tailed bat, the jaguarundi, the capybara, the tufted capuchin, the white-lipped peccary, the greater bulldog bat, the Southern Amazon red squirrel, the marsh deer, the water opossum, the red brocket, the brown-throated sloth, the black-capped squirrel monkey, the South American tapir, the southern tamandua, the moustached tamarin, the pacarana, etc.

[1] Birds reported for the lowland rainforest in the park include: the great tinamou, Spix's guan, the rufescent tiger-heron, the blue-and-yellow macaw, the silvery grebe, the harpy eagle, the long-billed starthroat, the snowy egret, the king vulture, the scarlet macaw, the roseate spoonbill, the blue-crowned trogon, the turquoise tanager, the Amazonian pygmy owl, the blue-headed parrot, etc.

[1] There are five areas open to tourists where local biodiversity can be watched along paths, swamps, oxbow lakes and river shores.

[1] In the lower basin of Manu river there are also: 5 camping sites, 4 viewing points (one of them an 18 m tower), 3 lodges and a canopy walkway.