He moved to first tier FC Basel in 2015, where he won consecutive league titles in 2015–16 and 2016–17, the latter of which was a double that included the 2016–17 Swiss Cup.

He joined Manchester City in 2022, winning a continental treble in his first season with the club, as well as numerous other trophies, including one more Premier League title in 2023–24.

Akanji played the full 90 minutes in all six games and helped the team finish second in its group, thus qualifying for the knockout phase.

[14] On 1 September 2022, Akanji joined Premier League champions Manchester City, signing a contract until 2027[15] for a reported fee of £15 million.

[19] On 17 May 2023, he scored his first goal for the club, which was also his first in the Champions League, with a header deflected by Éder Militão in a 4–0 home win over Real Madrid in the semi-final second leg.

[21] On 21 October 2023, Akanji received his first red card for Manchester City in a 2–1 win over Brighton & Hove Albion in the Premier League.

[citation needed] On 9 June 2017, Akanji made his debut for the Swiss senior team in a 2–0 win against Faroe Islands in a 2018 World Cup qualifying match, where he played the entire 90 minutes.

[30] He started all five of Switzerland's matches as they reached the quarter-finals,[31] scoring his kick as the Swiss beat France in a penalty shootout in the round of 16.

[34] Akanji was a member of the Swiss squad for the 2022 FIFA World Cup and, on 7 December 2022, he scored the only goal for Switzerland in a 6–1 loss to Portugal in the round of 16.

Akanji took the first spot kick for Switzerland in the shoot-out, which Jordan Pickford saved, and with both teams scoring their remaining penalties, England advanced by winning 5–3.

[41][43][44][45] His ability to read the game and make crucial interceptions as well as his calmness under pressure is well-known among fans of the English Premier League.

[41][44][46] Due to his passing abilities, Akanji has been deployed as both a left-back and right-back, as well as occasionally a libero, much like teammate John Stones, by City manager Pep Guardiola.