He spent the majority of his career as an actor and singer, but in 2005 moved to the United States primarily as a composer, music producer and arranger.
He spent most of his early years studying acting, music, dubbing, vocal, piano, and drums at the CTA (Centro Teatro Attivo) in Milan, and at age 14 he passed the SIAE composers examination.
In 1986, De Peppe played the character of "Matt" (the drummer of the band Beehive) in an Italian TV series called Love Me Licia, his first major role in broadcast television.
He collaborated with others including Peer Music, Bill Champlin, Tamara Champlin, Piero Cassano, Andrea Lo Vecchio, Ivana Spagna, Toto Cutugno, Marco Grasso, Pablo Manavello, Jorge Luis Cachin, Martha Cancel, Bernadette O'Reilly, Anthony Fedorov, Clara Serina, Franco Fasano, Danilo Amerio and Ariztia.
During His career, Manuel created, composed and arranged a lot of famous Commercial Jingles for European TV Channels like: Tamagotchy, Polaretti, Push Pop, Tanya Walking, Ralph, Pasqualone, Zaini Stranamore, Cicciobelli Amicicci, Giocheria".