Manuel De Sica (24 February 1949 – 5 December 2014) was an Italian composer.

Born in Rome, the son of Vittorio De Sica and María Mercader, De Sica enrolled at the Accademia Nazionale di Santa Cecilia, in which he studied with Bruno Maderna.

[3] In 1996 he won the David di Donatello for Best Score for Carlo Lizzani's Celluloide.

[3] De Sica also wrote chamber compositions and ballet music.

[4] De Sica died of a heart attack on 5 December 2014 at the age of 65.