[4][5] On 16 July 1913, Pérez de Guzmán married in the Church of San Miguel in Jerez de la Frontera, to María Dolores Moreno de Arteaga, and the couple had eleven children, Gregorio (1914–1978), Manuel (1915–1994), Francisco (1916–1995), Antonio, Cecilia (1919–1995), María Teresa, María Dolores (1922–1976), Luis Alfonso, Julia (1924–1974), José, María Concepción.

[7] As the eldest, he was the first Pérez de Guzmán to play in the club's first team, doing so in 1903, aged 15.

Together with William Waterson, Antonio Tellechea, Ángel Padilla, and Tomás Estrada, he was a member of the Huelva squad that participated in the 1906 Copa del Rey, which was contested by only three teams, the other two being Athletic Bilbao and Madrid FC (currently known as Real Madrid), with the latter winning it.

[8] When his father became the vice president of Recreativo de Huelva in 1906, he had four of his sons playing for the club, including Manuel.

[citation needed] Pérez de Guzmán died in Huelva on 22 January 1957, at the age of 68.