Her father tragically disappeared, her brother was mentally ill, and Manuela and her husband Lorenzo Caballero suffered from serious ailments.

[1] In Valladolid she premiered her play Sáfira, with great public success, as it was published in the Revista de Teatro (Theater Magazine).

In one entitled A la Coruña, she continues the fashion of exalting her homeland, describing the landscape in a pleasant and nostalgic way.

[3] She was the first Latin American woman to publish a novel in Venezuela, as a folletín of the Diario de Avisos between March and April 1853.

[4] She was part of the group called Hermandad Lírica (Lyrical Sisterhood), along with poets such as Amalia Fenollosa [es] – with whom she maintained an intense epistolary relationship – Vicenta García Miranda, Carolina Coronado, Ángela Grassi, and Robustiana Armiño [es].