[2] It sold flights and services from several airports in the UK with bases in Belfast City, Blackpool, Cardiff and Isle of Man.

The first three routes to be announced by Manx2 were from the Isle of Man to Belfast International and Blackpool on 15 July, followed by Leeds Bradford on 12 August 2006.

Manx2 added a Fairchild Metroliner from Flightline BCN to its fleet for a period and extended its route network to include Belfast City.

Routes to Belfast City and Blackpool were flown by two 19-seat[7] turboprop Let L-410 aircraft from European operator VanAir Europe.

[8] On 3 September 2007, Manx2 launched a new service connecting Manx2's base on the Isle of Man with Gloucestershire Airport, located at Staverton between Gloucester and Cheltenham, within an hour of major cities such as Birmingham and Bristol.

On 22 November 2012, Manx2.com announced a buy-out of its business by Citywing Aviation Services Ltd, a new company formed by a management buyout team.

Manx2 did not own any aircraft directly but by virtue of its branding and advertising, sold tickets on flights operated on its behalf by other airlines, with some painted in the Manx2.com livery.