Manzinus is a lunar impact crater that is located in the southern region of the Moon's near side.

The outer rim to the north-northeast is joined to the smaller Manzinus R, and the crest along that side is lower and forms a saddle.

The heavily eroded satellite crater Manzinus A lies along the southeastern inner wall.

The interior surface has been resurfaced in the past, and now forms a level, featureless plain that is marked only by a few tiny craterlets.

India's Chandrayaan-3 mission successfully landed near Manzinus U at 69.37 degrees south latitude and 32.35 degrees east longitude By convention these features are identified on lunar maps by placing the letter on the side of the crater midpoint that is closest to Manzinus.