The second season of Prison Break, an American serial drama television series, commenced airing in the United States on August 21, 2006, on Mondays at 8:00 pm (EST) on Fox.

The brothers, along with six other prisoners at Fox River State Penitentiary, manage to escape, and the second season follows a massive manhunt chasing the group.

Dallas was chosen because of its "resourcefulness, cost effectiveness and variety with regard to activities available for the crew", which was considered to be a major component for the final decision.

[29] Mike Duffy of the Detroit Free Press commended the premiere for delivering "rocking good entertainment," and living up to the standard set by the first season.

Duffy praised the "motley crew of cellblock characters" and the "taut, ingenious storytelling of series creator Paul T. Scheuring and his staff.

"[30] Robert Bianco of USA Today commented on the "harebrained absurdities that have swamped this show", and accused the writers of being "incredibly lazy" for the continuous use of the tattoo as an "all-purpose plot fix".

The reviewers found the biggest success factors to be "the constant swerves and twists" throughout the season, and "the development of the hero-villain relationship between Scofield and Mahone".

[33] Robert Bianco of USA Today said that Fichtner was a welcome addition to the cast,[31] and Andy Dehnart from MSNBC called Mahone the best new character of the second season.

Out of all regular primetime programming that aired during the 2005–2006 American television season, Prison Break ranked #51 out of #142, according to the Nielsen ratings system.