Baltasara de los Reyes married, on May 2, 1812, with Francisco Acosta, a skilled sailor of Portuguese origin, known as El Portugués.
The couple had two children: Juan Alejandro Acosta, a military man and marine general of the Dominican Republic who fought in the Dominican War of Independence, and Lucía Acosta.
She was one of the two hundred patriots who were at the Puerta del Conde when independence was proclaimed by the Trinitarios.
She hid Juan Pablo Duarte in her house while he was being pursued by the Haitian authorities.
During the struggle for Dominican independence, Baltasara de los Reyes displayed great courage and resilience for the cause.