María Josefa Lastiri Lozano (October 20, 1792 – 1846) was the wife of General Francisco Morazán and the First Lady of the Federal Republic of Central America, Honduras, El Salvador, and Costa Rica.
She was born on October 20, 1792, to her parents Juan Miguel Lastiri and Margarita Lozano y Borjas in Tegucigalpa.
She backed General Morazán's political and military activities, in which she lost the large capital her first husband inherited her at death.
Due to the constant fighting and turmoil in El Salvador at the time, she left the country and sought asylum in Costa Rica.
After Morazán's fall from power and execution in September 1842, Lastiri and her family left the country and returned to El Salvador.