From 2003 to 2010, she practiced in the town of Trinidad, Colorado, where she apprenticed under Stanley Biber, a pioneer in sex reassignment surgery, before going solo in July 2003.

[10][11] She has served as Obstetrics and Gynecology Department Chairperson at Swedish (Providence) Medical Center, and was named the only physician member of the Washington State midwifery board.

[13][14] She has also helped initiate transgender surgical education programs at Sheba Medical Center in Tel Aviv (2014), Icahn School of Medicine at Mount Sinai in New York (2016), Denver Health in Colorado (2018), and University of Toronto (2019).

[citation needed] Bowers is the current president of WPATH and has served on the board of directors for both GLAAD and the Transgender Law Center.

Working with local plastic surgeon, Abdullahi Adan, and others, this specific surgical venue is a first for Africa after the failed opening of the Pleasure Hospital[17] in Bobo-Dioulasso.

Bowers's first known television appearance was a role in "Ch-ch-ch-changes" (2004), a season 5 episode of CSI: Crime Scene Investigation that focused on transgender issues.

[20] The filmmakers examine the success of Dr. Bowers's practice, and the transgender people who travel to the town of Trinidad, Colorado, for sex reassignment surgery.

[21] Bowers appears as herself in the television documentary Gender Revolution: A Journey with Katie Couric (2017), and in the reality series I Am Jazz from 2016 to 2018 (seasons 3 through 6)[citation needed].

Talking to Emily Bazelon of The New York Times Magazine in June 2022, Bowers distanced herself from others interviewed by Shrier, stating: "The most important thing is access to care, and that is a much bigger problem than the issue of how the medical community and transition is failing people.

"[26] In 2005, Terry Keith, a pastor for the All Nations Fellowship church in Trinidad, told The Pueblo Chieftain "Our reputation as sex-change capital of the world has brought shame and reproach on the community.

"[27] After Pierre Foldès's study in The Lancet (February 2012), his results were met with skepticism from British gynecologists who wrote a rebuttal to his findings, questioning his methods and outcomes.