Marco Mendoza started his professional career in 1989, playing bass for former Black Sabbath drummer Bill Ward's solo album Along the Way, which was released in January 1990.

In 1994, he was recruited into a reformed lineup of Thin Lizzy, also featuring Sykes, with guitarist Scott Gorham, keyboard player Darren Wharton and drummer Brian Downey.

After Sykes left Thin Lizzy in 2009, Mendoza rejoined the band for a third stint, this time with Gorham, Wharton, Downey, singer Ricky Warwick and guitarist Vivian Campbell.

The record was produced and co-written by Richie Kotzen and features guest performances by Steve Lukather, Ted Nugent, Doug Aldrich, Tommy Aldridge, Brian Tichy, Marco Rentería of Jaguares, and others.

Mendoza has also played for the band Soul SirkUS and with many other artists from different musical backgrounds including: Bill Ward, Right Said Fred, Robert Williams, Roch Voisine, Dolores O'Riordan, Tim "Ripper" Owens, and Tommy Shaw.