For his performance of Comandante in the film Mexican Gangster: La Leyenda del Charro Misterioso he received a Diosa de Plata nomination for Best Supporting Actor.

He received further recognition for playing record producer Sergio Andrade [es] in the Mexican film Gloria, for which he was nominated for a Diosa de Plata and won the Ariel Award for Best Actor in 2016.

[6][7] Pérez and Huerta re-teamed in 2015 in the film Mexican Gangster: La Leyenda del Charro Misterioso, directed by José Manuel Cravioto.

Pérez was cast as Guadalupe Robles (a role based on real life drug trafficker Ramón Arellano Félix) in the TV series El Señor de los Cielos.

[13] Pérez received mixed critical reviews for his performance; Jessica Oliva of Cine Premiere magazine stated that "Marco Perez [Sergio Andrade] manages to embody the duality of that genius of the industry, perverse and visionary at the same time".

[15] Sofía Ochoa and Verónica Sánchez of En Filme were critical about the fact that Pérez was "flat", with no further explaining on how Andrade achieved his domain over women, "drawing a caricature of a public figure, [that] not only was complex and imposing, he was talented to some extent, very Machiavellian, ambitious, egotistical, narcissistic and unscrupulous".

[16] David Noh of Film Journal International also gave a negative review, since the actor "is too unremittingly slimy and completely lacking in magnetic charisma to be convincing as such an irresistible and titanic A&R lothario".