She began her artistic preparation at the National Conservatory of Music, and followed with studies at Casazul in Mexico, Claudio Tolcachir's school in Argentina, the Stella Adler Studio in New York City, and the Royal Academy of Dramatic Art in London.

Espinosa is also featured in several other films including Sea of Dreams (2006), La Vida Inmune (2006), El Brassier de Emma (2007), The Kid: Chamaco (2009), I Miss You (2010), Vete Más Lejos, Alicia (2010), and Asteroide (2014).

[2] She continued her studies at the Claudio Tolcachir school in Argentina, the Stella Adler Studio in New York City, and the Royal Academy of Dramatic Art in London.

[14] Espinosa and Pérez received positive reviews for their performances from Jessica Oliva of Cine Premiere magazine, who stated that the actors "seem to blend in with their characters.

Sofía Espinosa stands out with her voice (singing all the songs), and her physical interpretation and charisma, while Marco Pérez, Sergio Andrade, manages to embody the duality of that genius of the industry, perverse and visionary at the same time".

[15] Sofía Ochoa Rodríguez and Verónica Sánchez of En Filme were "surprised by [Espinosa's] performance" as it was "very close to Gloria Trevi's, albeit with a nasally accent, and cadence which lets through the hoarse, sarcastic and melancholic style that permeates on every one of the songs the actress sings.

Her acting work and physical resemblance let her move naturally from comedy to pain, loneliness to longing, to the easy smile, to the dance, to the jumps on stage and the twinkle in her eyes".

[16] In contrast, David Noh of Film Journal International was not impressed by Espinosa's acting, saying that she "lacks appeal and is quite ordinary in a role that calls for some of the electricity the very young Jennifer Lopez managed to ratchet up in her musical biopic, Selena".

[19][20] In 2015, she played Graciela Arias in the film Los Crímenes de Mar del Norte, based on the true story of Goyo Cárdenas, the strangler of Tacuba.

[30] Espinosa funded with fellow actors Belén Aguilar, Fernanda Echevarría and Armando Espitia the theater company Conejo Sin Prisa[31] and debuted an adaptation of Paula Vogel's play How I Learned to Drive on May 15, 2017, at the Centro Cultural del Bosque (es) in Mexico City.