Wilfredo Jose Ledezma Acosta (born January 21, 1981) is a Venezuelan former professional baseball pitcher.

He played in Major League Baseball (MLB) for the Detroit Tigers, Atlanta Braves, San Diego Padres, Arizona Diamondbacks, Washington Nationals, Toronto Blue Jays, and Pittsburgh Pirates, and in Nippon Professional Baseball (NPB) for the Chiba Lotte Marines.

Ledezma was originally signed by the Boston Red Sox as an amateur free agent in 1998.

Between 2004 and 2007, he alternated between pitching for the Tigers and for the AA Erie SeaWolves and AAA Toledo Mud Hens.

He had gone home to Venezuela during the All-Star break, during which he accidentally damaged his visa and passport in the washing machine.

On July 31, 2007, Ledezma was traded to the San Diego Padres for reliever Royce Ring.

On August 29, 2008, Ledezma was claimed off waivers by the Arizona Diamondbacks and appeared in 3 games for them before he was non-tendered following the season, becoming a free agent.

On November 30, 2009, Ledezma signed a minor league contract with the Pittsburgh Pirates, with an invite to Spring training.

The Pirates designated Ledezma for assignment on December 24, 2010, to clear roster space after signing free agent pitcher Aaron Thompson.

[8] In November 2011, he signed a minor league contract with the Los Angeles Dodgers that contained an invitation to spring training.

[13] On December 23, 2014, Ledezma signed a minor league contract with the Minnesota Twins organization that contained an invitation to spring training.

On May 27, 2016, Ledezma signed with the Rojos del Águila de Veracruz, where he logged a 2.03 ERA in 30 appearances.

On June 27, 2021, Ledezma signed with the Tecolotes de los Dos Laredos of the Mexican League.