On April 1, 2002, Lisson signed with the Kansas City Royals organization as an international free agent.

Lisson did not play in 2003 and spent the 2004 season with the rookie ball Idaho Falls Chukars, slashing .289/.398/.438 with 8 home runs and 49 RBI.

On January 25, 2010, Lisson was designated for assignment by the Royals to clear room on the 40-man roster for Rick Ankiel.

He elected free agency after the season and again re-signed with Kansas City on November 10, on another minor league deal.

On January 7, 2014, Lisson playing for the Magallanes tied a mark in the Venezuelan League with three home runs in a postseason game.

On December 13, 2013, Lisson signed a minor league contract with the San Francisco Giants organization.

[8] He split the year between the Triple-A Syracuse Chiefs and the Double-A Harrisburg Senators, slashing .269/.321/.366 with 6 home runs and 37 RBI.

In January 2022, The Nationals named Lisson the manager of Single-A Wilmington Blue Rocks for the 2022 season.