She wrote dozens of research papers on the chemistry of the natural world and assaying methods.

[2] Beginning in 1918, she worked on the United States Geological Survey, developing ways to detect minerals within naturally occurring bodies of water.

[3] Methods pioneered by her include those for quantifying manganese, boron, fluoride, and sulfate, devised in connection with earning her post-baccalaureate degrees.

[2] In this capacity, she worked on the Manhattan Project, developing two new techniques of quantitative analysis, one for uranium and one for thorium,[4] as well as two new ways to separate the two elements.

[3] Upon her return to the Geological Survey after the war, she researched the chemistry of clay minerals and micas.