In 2021, George authored an immersive audiovisual step inside a story tour for the Circus Maximus in Rome entitled The Charioteer on the BARDEUM mobile app.

She worked as a science writer for several years at the National Institutes of Health in Bethesda, Maryland before moving to Madison, Wisconsin with her husband.

Almost thirty years after its publication, it is still influential and was at the top of the fans' recommended Henry VIII fiction list for The Tudors miniseries.

[19] Her other books show the same key characteristics: careful research almost qualifying for non-fiction standards, enough length to give perspective to the subject's life, and colorful imagery.

Mary, Called Magdalene (2002) was published a year before Dan Brown's The Da Vinci Code and was based on the historical facts.

Margaret George’s knowledge of ancient medicine, acquired through her background in biology and her research on Cleopatra, Mary Magdalene, Helen of Troy, and Nero, has led to her speaking on the subject at various venues.