Margaret Hutchinson Rousseau (27 October 1910 – 12 January 2000) was an American chemical engineer who designed the first commercial penicillin production plant.

[4] Her thesis topic was The effect of solute on the liquid film resistance in gas absorption.

During the Second World War, she oversaw the design of production plants for the strategically important materials of penicillin and synthetic rubber.

[2] Her later work included improved distillation column design and plants for the production of ethylene glycol and glacial acetic acid.

[5] An ethylene glycol plant was recently in the process of construction deep in the heart of Texas, when an indignant workman watching a tall, blonde beauty boss the project, said to his foreman: "Who does that dame think she is, strutting around here?"