She was a sister of the poet Thomas Wyatt[1] and a friend of Queen Anne Boleyn, second wife of King Henry VIII of England.

A portrait by Hans Holbein the Younger shows a woman presumed to be Margaret at the age of thirty-four, and it is assumed that it was painted around 1540.

As Mistress of the Queen's Wardrobe, she would presumably have played a leading part in the decadent social life at court in the mid-1530s, which was fuelled by the extravagance of Henry and Anne.

Lady Margaret was sent to attend her royal mistress in the Tower of London in May 1536 when the Queen was arrested on charges of adultery, treason and incest.

Grimald's funeral elegy, "An Epitaph of the Lady Margaret Lee", advises the reader, "Man, by a woman learn, this life what we may call," and praises her "blood, friendship, beauty, youth," and other qualities (no.