Margaret Tyndal was born into an Essex gentry family: her father Sir John Tyndal was a Master of the Court of Chancery, and her mother Anne Egerton was related to several of the leading Puritan clergy of the time; Anne was the sister of Stephen Egerton, who in turn married Sarah, daughter of Thomas Crooke.
She moved to the estate of John Winthrop's father, Groton Manor in Suffolk, helping him manage the household while her husband was away working in London.
"Prior to parting, the two agreed to set aside five to six o'clock every Monday and Friday to think of one another and enter into spiritual communion with each other till the time they were reunited.
"[1] Margaret arrived in New England on 2 November 1631, having sailed on the Lyon, and was admitted to Boston church as member #111.
She and John Winthrop had eight children: Stephen, Adam, Deane, Nathaniel, Samuel, Anne, William, and Sarah.