[2] Born to an Armenian father, Melik, and a Russian mother, Lyudmila, Gasparyan began playing tennis at age 5.

At the end of the 2013 season, Gasparyan was called by Shamil Tarpischev to be part of the Russian team for the Fed Cup Final against Italy, in early November.

In May, Gasparyan made her Grand Slam main-draw debut at French Open, where she lost in two sets to Ana Konjuh as a qualifier.

At the Kremlin Cup, Gasparyan upset ninth seed Kristina Mladenovic in the second round but lost to eventual finalist Anastasia Pavlyuchenkova in the quarterfinals.

In her last tournament of the year, Gasparyan reached the quarterfinals of the WTA Challenger Open de Seine-et-Marne, retiring in the match against Francesca Schiavone.

At the Indian Wells Open, Gasparyan lost to ninth seed Roberta Vinci in the second round, despite having two match points.

[7] Gasparyan came back to tennis in late 2017, participating in the qualifying rounds of the Kremlin Cup, after experiencing three knee surgeries.

She then entered her first WTA tournament since coming back from injury, the Jiangxi International Open in Nanchang, China, reaching the second round where she lost to Zhang Shuai.

Gasparyan started her season at the Australian Open where she reached the second round, losing to Elise Mertens in straight sets.

[18] She then qualified for the main draw at the St. Petersburg Ladies' Trophy,[19] but lost to former Grand Slam champion Victoria Azarenka in the first round.

[20] Despite her early exit in singles, she managed to win the biggest doubles title of her career alongside Ekaterina Makarova in St. Petersburg as an unseeded pair.

[23] Gasparyan returned stronger during the grass-court season, upsetting seventh seed Viktória Kužmová in the first round of the Rosmalen Grass Court Championships.

[31] Gasparyan began 2020 by qualifying for the main draw at the Shenzhen Open, but lost to second seed Aryna Sabalenka in convincing fashion.

She ended a six-match losing streak at the US Open, defeating former Olympic gold medalist Monica Puig in three sets, which was her second top 100 victory of the season.

[35] Held during the second week of the US Open, Gasparyan made the second round of the İstanbul Cup but was forced to retire against Rebecca Peterson due to an injury.

[38] Handed a wildcard at the St. Petersburg Ladies' Trophy, Gasparyan beat Kateřina Siniaková to reach her first WTA 500 quarterfinal since 2015.

[39] Continuing her good form, Gasparyan defeated top seed Ekaterina Alexandrova in straight sets[40] and Vera Zvonareva to reach the biggest final of her career.

[43] She endured through a five-match losing streak on clay, with her last match of the season being a comprehensive loss against Ann Li in the first round of the French Open, winning just one game.

[45] Betova lost her rankings, before she came back in February 2023 and played her first qualifying matches at the 2023 Abu Dhabi Open and the 2023 Dubai Tennis Championships.

[46] Again using her protected ranking, Betova entered the 2024 Hong Kong Tennis Open, but lost in the first round to qualifier Shi Han.