Rosa Margarita Villalta de Sánchez (born 4 April 1950) is a Salvadoran activist, politician and public figure.

[1] As the country's Second Lady, Villalta de Sánchez served as the coordinator of the Comisión de Acción Social (CAS), commission under the Vice President's office which developments programs for women and children in the country.

[2] Margarita Villalta de Sánchez became the First Lady of El Salvador on 1 June 2014, upon the inauguration of her husband, a former leftist rebel commander during the Salvadoran Civil War.

On 11 June 2014, Margarita Villalta de Sánchez was sworn in as the Director of the Instituto Salvadoreño para el Desarrollo Integral de la Niñez y la Adolescencia (ISNA), a government organization which works with children and adolescents.

In July 2014, the couple converted the Casa Presidencial into a museum and arts center, featuring the works of 45 Salvadoran artists.