After The Station, she became a premier star featuring in Italian box office hits like Carlo Verdone's Damned the day I met you (1992).

She teamed up again with director Daniele Luchetti for The Storm Is Coming (1992) and worked with Mario Monicelli in Looking for Paradise (1995) and Pozzessere (An Eyewitness Account).

She also formed an association with Italian director Giuseppe Piccioni, who directed her in four films: the most important being Penniless Hearts (1996) and Not of this World, which earned Margherita her second David di Donatello Award.

Now Margherita Buy is one of the most appreciated actresses of European cinema: Ferzan Özpetek's The Ignorant Fairies, in which she portrayed a widow who discovered her husband had been having an affair with a man for the last seven years won her a Silver Ribbon as best lead.

Il caimano by Nanni Moretti, shown at the 2006 Cannes film festival, gave her the Ciak d'oro 2006 award as best lead actress.