Margherita Maccapani Missoni was born in Italy[3] and grew up in the Italian countryside, spending weekends in Milan.

Margherita has studied philosophy both at the Università Statale di Milano and at the Columbia University in New York where, following that period, she also attended the Stella Adler acting school and the Lee Strasberg Theater Institute.

[5] However, after she moved to New York, she struggled emotionally when her academic credits could not transfer to the United States educational system.

[3] Before she was featured in Missoni campaigns, she was a company ambassador, a duty entailing promotion at fashion related events.

[7] Since the spring of 2009, Margherita started getting involved with the brand on a different level, becoming part of the design team, following the footsteps of her mother Angela, the Maison's Creative Director.