The business was founded in 1953, when Ottavio and Rosita Missoni set up a small knitwear workshop in Gallarate, Italy.

[2] Rosita told the models to remove their bras, supposedly because they were the wrong colour, and showed through the thin lamé blouses.

[6] From 2007 until 2009, Massimo Gasparini briefly served as the company's CEO, setting up a new organizational structure and streamlining its product offer.

[10] On 27 June 2013, the Venezuelan government announced that remains of the aircraft had been found north of Los Roques archipelago.

[20] In October 2024, Missoni announced the departure of Grazioli and the reappointment of Alberto Caliri to the creative director position.

[2][7] Missoni Sport was relaunched in 2022,[24] now produced in-house as a wellness and comfort line, retailing at around 20 per cent less than the signature brand.

[20] In 2023, it launched a capsule collection of tracksuits, cardigans, hoodies and sweatshirts in collaboration with soccer player Mike Maignan.

[2] In 2012, Missoni Home launched its cooperation with the 645-unit Acqua Livingstone tower in Manila, as the first residential building in the world for the brand to fully equip.

By 2023, a Missoni Resort Club outpost opened in collaboration with Nikki Beach Costa Smeralda in Porto Cervo.

[33] Missoni operated a licence with Children Worldwide Fashion until early 2000s, when it was brought in-house with a more restricted product offer.

[34] The company launched its first perfume – manufactured by Charles of the Ritz[35] and developed and distributed by Max Factor[36] – in 1982,[2] although the license is now held by Estée Lauder.

[43] Over the years, Missoni has commissioned various notable photographers for its ad campaigns, including Juergen Teller (2010)[44] and Alasdair McLellan (2013).